By Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick
This quantity bargains a entire advisor at the concept and perform of amorphous stable dispersions (ASD) for dealing with demanding situations linked to poorly soluble medications. In twenty-three inclusive chapters, the booklet examines thermodynamics and kinetics of the amorphous nation and amorphous stable dispersions, ASD applied sciences, excipients for stabilizing amorphous stable dispersions equivalent to polymers, and ASD production applied sciences, together with spray drying, scorching soften extrusion, fluid mattress layering and solvent-controlled micro-precipitation know-how (MBP). every one expertise is illustrated by way of particular case reviews. furthermore, devoted sections hide analytical instruments and applied sciences for characterization of amorphous sturdy dispersions, the prediction of long term balance, and the improvement of compatible dissolution tools and regulatory facets. The booklet additionally highlights destiny applied sciences at the horizon, reminiscent of supercritical fluid processing, mesoporous silica, KinetiSol®, and using non-salt-forming natural acids and amino acids for the stabilization of amorphous systems.
Amorphous reliable Dispersions: concept and perform is a worthwhile connection with pharmaceutical scientists attracted to constructing bioavailable and therapeutically powerful formulations of poorly soluble molecules with a purpose to develop those applied sciences and advance larger medicinal drugs for the future.
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Amorphous Solid Dispersions: Theory and Practice (Advances in Delivery Science and Technology) by Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick